Predicting the Flow Stresses in a Bioreactor

Tan BT, Liow K, Hourigan K, Sheridan J, Thompson MC, 11th Asian Congress of Fluid Mechanics, 22-25 May, K.L., 2006

The axisymmetric flow in a simplified bioreactor is simulated in this study. A method of quantyfying the stress levels in three dimensional flow is presented. Passive tracer particles are used to simulate the trajectory of the cells. Next we analyse the stresses experienced by the cells as a result of the mechanical agitation of the bioreactor. Statistical measurements are made with the aim of predicting the stress histories of cells cultured in bioreactors.