Publication

A Novel Formulation and Optimization of Aspirin Nano-emulsion prepared by Cavitation induced by Ultrasonic waves.

Siah Ying Tang, Manickam Sivakumar, Journal of Industrial Technology, 9(1):179-196., 2010

The preparation of poorly water soluble drugs in the form nano-emulsion is of increasing interest in the current drug delivery system, as it appears as an excellent drug vehicle to facilitate the delivery of hydrophobic pharmaceutical ingredients into gastrointestinal tract, thereby improve the drug oral bioavailability. In the present study, an energy efficient ultrasonic cavitation method was utilized to prepare a well- optimized formulation of aspirin nano-emulsion by using a 20 kHz ultrasonic horn processor. It was found that optimum level in terms of emulsion composition, acoustic amplitude, and ultrasonic processing time is crucial to achieve minimum droplet size. The present paper demonstrated that O/W nano-emulsions system of 20 wt% Lauroglycol® FCC and balance water with average droplet diameter as low as 232 nm could be achieved with the presence of 5wt% Cremophore-EL as surfactant. Results are comparable to those emulsions prepared with a magnetic stirrer and an ultra-turrax homogenizer. The microscopic results showed that the emulsion droplet after 1 min ultrasound irradiation were almost spherical in shape and excellently stable with no apparent flocculation and coalescence over the two-week storage at room temperature. It strongly suggested that the use of ultrasound for preparation of O/W aspirin nano-emulsions was superior in terms of droplet size and energy efficiency, as compared to conventional magnetic mechanical devices.